Nanotherapeutics in Oncology: Dendrimers the Nano Wonder

Oligonucleotide dendrimers: stable nano-structures.

DNA dendrimers with two, three, six, nine or 27 arms were reassociated as complementary pairs in solution or with an array of complementary oligonucleotides on a solid support. In all cases, duplex stabilities were greater than those of unbranched molecules of equal length. A theoretical treatment for the process of dissociation of dendrimers explains the major properties of the complexes. The ...

pH-dependent nano-capturing of tartaric acid using dendrimers.

The ability of dendrimers to bind to various target molecules through non-covalent interactions was used to capture water soluble organic reagents, such as tartaric acid (TA), from different matrices, i.e. aqueous solutions and wine samples. The influence of the pH, dendrimer type, generation and feeding concentration on the host-guest complexation of TA was investigated. The maximum binding ca...

Nano-patterning of solid substrates by adsorbed dendrimers.

Weakly charged solid substrates can be nano-patterned in liquid-like order with large and well-defined spacing by adsorbing poly(amido amine) (PAMAM) dendrimers; highly charged substrates lead to lower spacing due to electrostatic three-body attractions between the dendrimers and the substrate.

The matching interdiction problem in dendrimers

The purpose of the matching interdiction problem in a weighted graph is to find two vertices such that the weight of the maximum matching in the graph without these vertices is minimized. An approximate solution for this problem has been presented. In this paper, we consider dendrimers as graphs such that the weights of edges are the bond lengths. We obtain the maximum matching in some types of...

Targeted nanotherapeutics in cancer